Anti-IgLON5 disease is a rare (ORPHA:420789, www.orpha.net, last accessed on 14 March 2022) late-onset (median 62 years [1]) neurological disease associated with autoantibodies against IgLON5 [2], a cell-surface protein of unknown function [3] preferentially expressed in neurons [4]. Here, IGLON5 is linked to nervous system disorder.