They examined the regulatory role of ST32db in the β3-adrenoceptor (β3-AR)/protein kinase A(PKA)/p38 pathway and tried to explain the anti-obesity effect of ST32db in terms of this pathway, because a prior study pointed out that it is an important mechanism for the induction of UCP1 in WAT browning [41]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.