Hepatic stellate cells stimulated by norepinephrine favor HCC progression by enhancing the proliferation, EMT, and stemness properties of HCC cells, notably through the secretion of secreted frizzled-related protein 1 (sFRP1), which activates the Wnt16B/β-catenin pathway in hepatic cancer cells [137]. This evidence concerns the gene FRZB and hepatocellular carcinoma.