Induced pluripotent stem cells (iPSCs) expressing LRRK2 G2019S and R1441C are reported to show) decreased activity of GBA (glucocerebrosidase), an enzyme localized in the lysosomes known as a risk factor for PD, through regulation of RAB10, a LRRK2 kinase substrate [22]. The gene discussed is GBA1; the disease is Parkinson disease.