TGFB1 and neoplasm: MSCs can also promote immune evasion of tumor cells in the TME, and it was found that human umbilical cord mesenchymal stem cells (hUCMSC)-derived exosomes containing miR-3940-5p were able to downregulate EMT, metastasis and invasion of DLD-1 colorectal tumor cell line through decreasing the integrin α6 (ITGA6) expression and inhibiting the activity of TGF-β1 signaling pathway [108].