NLRP3 inflammasome, a typical Nod-like receptor, is also an important PRR in sepsis, and it has been reported that exosomes released from LPS-treated macrophages could induce NLRP3 inflammasome and caspase-1 activates and induces the release of the proinflammatory factor IL-1β [50,51]. This evidence concerns the gene IL1B and Sepsis.