EAE was established in two types of AD mouse models, APPswe/PSEN1ΔE9 (APP/PS1) and 5xFAD transgenic (Tg6799) mice, and we found that the clinical symptoms of EAE were significantly ameliorated in APP/PS1 mice compared to their wild-type (WT) littermates. The gene discussed is PSEN1; the disease is Alzheimer disease.