IFNB1 and infection: Additionally, the demethylation of the downstream of the IFN-β (interferon-beta) gene, one of the main factors in the immune system response, transcription start site in 1A5 and 28E10 cells has been shown to result in the inhibition of viral replication, as the viral titer was decreased 80 to 90% 72 h post-infection [107].