Regarding the significant associations and conflicting results between genetic markers and AMD [22] in previous studies, we aimed to investigate the associations between four single nucleotide polymorphisms (SNPs) in VEGFA (OMIM* 192240), and VEGF-A and VEGFR-2/KDR protein roles in AMD in the Caucasian population to focus on a potential tool for early diagnosis. The gene discussed is VEGFA; the disease is age-related macular degeneration.