VEGFA and age-related macular degeneration: Moreover, an extensive analysis of VEGFA promoter and gene polymorphisms showed that SNPs +674, +4618, +5092, +9162, and +9512 their haplotypes, CTCCT and TCACC, were associated with a 15-fold increased risk of exudative AMD and the promoter SNPs −460T, −417T, −172C, −165C, −160C, −152G, −141A, −116A, +405C haplotype was associated with about an 18-fold greater risk [19].