One CAR contained T cell-specific domains with transmembrane and costimulatory domains derived from CD28 sequences and CD3ζ as the signaling domain (CD3ζ CAR), as CD3ζ has been shown to be functional in the context of CAR MΦs designed to target other tumor-associated antigens (TAA) (20,21). The gene discussed is CD28; the disease is neoplasm.