IGFBP3 and coronary artery disorder: Indeed, they demonstrated that the BAT-specific genes UCP-1, PGC-1α, PRDM16 and bone morphogenetic protein 7 (BMP7) were statistically significant lower in CAD patients and WAT-specific gene insulin-like growth factor binding protein 3 (IGFBP3) and HOXC9 were significantly higher compared to non-CAD patients, which suggests a change in the composition of the EAT in CAD patients.