HLA-C and ovarian carcinoma: As reported above, Withaferin A (WFA), which is extracted from the plant Ashwagandha (Withania somnifera), could ameliorate cardiac dysfunction in an experimental model of female mice with ovarian cancer by reversing systolic function, revoking the decrease in the size of the cardiac myocytes, ameliorating cardiac fibrosis, abrogating MHC isoform shifting, and significantly reducing the circulating AngII and proinflammatory cytokines [18].