In an in vitro model of CF induced by interleukin-1β or Pseudomonasaeruginosa lipopolysaccharide-stimulated bronchial epithelial cell lines, NFkB decoy ODNs coated with polysialic acid-N-trimethyl chitosan or poly(D,L-lactide-co-glycolide), large porous particles efficiently reduced the secretion of multiple pro-inflammatory mediators of CF [53,54]. The gene discussed is NFKB1; the disease is cystic fibrosis.