EGR1 and cardiovascular disorder: Intriguingly, miR-19a decreases cell apoptosis and necrosis via repression of Bim, a proapoptotic protein, and switches on autophagy in rat cardiomyocytes under hypoxia [103]; equally important, miR-30e-3p promotes cardiomyocyte autophagy and inhibits apoptosis by indirectly regulating the expression of Egr-1 (Early growth response-1), a zinc finger transcriptional protein that has been associated with cardiovascular disorders [104], in an ischemic/hypoxic environment [105].