Alterations of the expression of regulatory elements that mediate IL-2 transcription such as NF-κB, NFAT-c2, PP2A, microRNAs (e.g., miR-200a-3p) and phosphorylated cAMP-responsive element modulator (p-CREM) are evident in patients with SLE [45,46,47,48]. The gene discussed is IL2; the disease is systemic lupus erythematosus.