In addition, MRL/lpr lupus-prone mice knocked out for IL-23 receptors (IL-23R) revealed less severe LN, which was mechanistically explained by the restoration of IL-2 and a decrease in IL-17 production by T cells [49], together with reduced TFH and APCs, and reduced anti-dsDNA levels. Here, IL23R is linked to systemic lupus erythematosus.