In a study [12], we found that the NO-sGC-cGMP pathway plays a significant role in lung bronchodilation, and that lung sGC becomes dysfunctional in asthma due to high levels of NO generated from iNOS induction during inflammation in the airway epithelium [12,115] which desensitizes the sGC resident in the airway smooth muscles below. Here, SGCB is linked to asthma.