NOS2 and cancer: This is now more evident from the fact that Hsp90 regulates the heme maturation of three key hemeproteins (iNOS, sGC and Hb) and our studies [21,59,60] now link the activation of sGC to the maturation of the globins (Mb/Hb), thereby contributing to the formation of novel NO-sGC-Globin axes and brings this pathway into a “new light” whose significance has thus far not been explored in cancer cells.