To understand the adaptive responses of the thyroid gland to Xb130 deficiency and the consequent hypothyroidism, we performed microarray-based transcriptomics analyses on thyroid tissues collected at three age points: W2 (before visible growth retardation); W4 (at the nadir of growth); and W12 (immediately before full growth recovery). This evidence concerns the gene AFAP1L2 and hypothyroidism.