HMGCR and type 2 diabetes mellitus: In fact, a large meta-analysis of two HMGCR single nucleotide polymorphisms (SNPs), including 43 studies with 223,463 individuals, and randomized controlled trials of statin treatment in 129,170 participants, concluded that the HMGCR SNPs and statin treatment were similarly associated with lowering LDL-C concentration while raising the risk for increased BMI and type 2 diabetes [10].