Also, TIM-3 was more frequently expressed by TIGIT+ Vδ1 T cells than by TIGIT− Vδ1 cells from PBLs (p = 0.013), MALs (p = 0.0003), and TILs (p = 0.016; Figure 4C), however, the frequency decreased with tumor proximity (Figure 4C,D). This evidence concerns the gene HAVCR2 and neoplasm.