In Hashimoto thyreoiditis, another IgG-mediated autoimmune disorder, FcRn expression in thyroid epithelial cells was shown to be reduced, and interferon-γ (IFN-γ), tumor necrosis factor-α, and interleukin-4 or -10 treatment diminished FcRn expression [63]. The gene discussed is FCGRT; the disease is autoimmune disease.