Additionally in colitis models, mice with transgenic human VDR in IECs exhibit a mucosal barrier protection mechanism as elucidated by preserved TEER, reduction in IEC apoptosis, caspase-3 deactivation, and downregulation of p53-upregulated modulator of apoptosis (PUMA), an important inducer of IEC apoptosis in IBD [183]. This evidence concerns the gene VDR and inflammatory bowel disease.