This MM-STAT3 signature includes B-cell CLL/lymphoma protein family (BCL3 and BCL6), JUN oncogenes (JUN and JUNB), interferon regulatory factor (IRF1 and IRF9), Bcl2 family (MCL1), protein tyrosine phosphatase type IVA, member 3 (PTP4A3, also named as PRL-3), etc. BCL6 variant 2 is absent in normal plasma cells, but upregulated by STAT3, which is bound on the promoter region of the BCL6 gene in IL-6-dependent MM cell lines. Here, PTP4A3 is linked to Miyoshi myopathy.