Tau protein can induce changes in Kv4.2 expression dendrites of CA1 pyramidal cells, which alters their excitability and synaptic plasticity [210], as Tau transgenic animals become older, their neurons exhibit depolarized neuronal resting membrane potentials [207,208,209], increased evoked action potential firing [211,212,213] and are more prone to induced epilepsy [214,215]; a finding consistent with studies demonstrating increased seizure prevalence in patients with AD [191,216,217,218,219,220,221,222]. Here, MAPT is linked to Alzheimer disease.