For example, social isolation and injuries caused by induced cerebral hypoperfusion result in memory deficits that correlate with decreased levels of α-tubulin and MAP2 [165,166] The cognitive impairment in senescence-accelerated (SAMP10) mice also correlates with a reduction in MAP2 and a simplification of the dendritic arbor [167]. Here, MAP2 is linked to Cognitive impairment.