The concentration levels of IL-1β in SeD patients were found to be higher when compared to MD and MOD patients, as well as MD + PTSD and MOD + PTSD patients (mean and standard deviation analysed with a significance level of = 0.05 for the MD + PTSD and MOD + PTSD groups is shown in Table 1). This evidence concerns the gene IL1B and spondyloepiphyseal dysplasia.