Comparing and contrasting of mGluR5 expression in participants with FXS, related conditions, and healthy participants with TD, particularly in insular, temporal, and cingulate cortices, the regions with high of mGluR5 expression in healthy men with TD [60], will greatly enhance anatomical localization of mGluR5 expression in FXS and related conditions. This evidence concerns the gene GRM5 and fragile X syndrome.