Due to the negligible levels of FMRP in men with the FM, we included in our analyses data from a man with an FXS-M with a premutation allele of 181–189 CGG repeats close to the allele size of people with the FM (>200 CGG repeats) because he contributed a larger value of FMRP. This evidence concerns the gene FMR1 and fragile X syndrome.