MARK2 and stroke disorder: For example, 4q25 region of chromosome 4 [39] and a variant of the ZFHX3 gene in the 16q22 region of chromosome 16 [40] were associated with ischemic stroke and atrial fibrillation, 9p21 region was associated with stroke and diabetes [62], and serine/threonine kinase gene (STK39) variants were associated with stroke and hypertension [63].