Therefore, we investigated the attenuating effects of Artemisia gmelinii ethanol extract (AGE) on lung inflammation by suppressing NF-kB/MAPK activation in a CS extract (CSE)/lipopolysaccharide (LPS)-stimulated alveolar macrophage cell line (MH-S) and CSE/porcine pancreatic elastase (PPE)-induced mouse model of COPD. The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.