In fact, we have shown through animal studies that genetic and pharmacological activation of NRF2 ameliorates many pathological conditions, such as multiple sclerosis [18], chronic obstructive pulmonary disease (COPD) [19], Alzheimer’s diseases [20], diabetes mellitus [21], and sickle cell disease (SCD) [22,23]. The gene discussed is NFE2L2; the disease is Schnyder corneal dystrophy.