To answer this question, a study with sickle murine model mice in which KEAP1 was specifically deleted in myeloid lineage cells (SCD::Keap1F/F::LysM-Cre) or endothelial cells (SCD::Keap1F/F::Tie1-Cre) has been carried out [103]. This evidence concerns the gene TIE1 and Schnyder corneal dystrophy.