By crossing SCD model mice harboring a mutant human β-globin gene (hβS/S) [101] with Keap1-knockdown mice (Keap1F/−), compound hβS/S::Keap1F/− sickle mice that harbored systemic and constitutive activation of Nrf2 expression were obtained. The gene discussed is KEAP1; the disease is Schnyder corneal dystrophy.