Consistently, the results of gene silencing of Src, EGFR, and AKT using si-Src, si-EGFR, and si-AKT siRNAs, respectively, confirmed the regulatory function of Src, EGFR, and AKT in the suppression of LCA-stimulated IL-8 expression by piperine in HCT-116 cells (Figure 3I,J). The gene discussed is EGFR; the disease is Leber congenital amaurosis.