EGFR and chronic obstructive pulmonary disease: A recent study has shown that EGFR-dependent IL-8 expression by human airway epithelial cells occurs in 2,3-butanedione-induced occupational bronchiolitis obliterans [38] Consistently, Ganesan et al. reported that aberrant EGFR activation contributes to increased IL-8 expression in chronic obstructive pulmonary disease airway epithelial cells [39].