IL6 and Cognitive impairment: The studies included in this review showed that GB generally and safely improved neuropsychiatric symptoms (SKT, NPI, and MMSE scores), cognition, mood, HbA1C, glycemia, waist circumference, BMI, atherosclerotic lesions formation, pro-inflammatory biomarkers (e.g., IL-6), and quality of life in healthy patients and subjects with mild cognitive impairment or vascular cognitive impairment.