A recent study [29], demonstrating the conglomerates of fragmented membranes, vesicles, and organelles (including damaged mitochondria), interspersed with α-synuclein inclusions, in Lewy bodies from PD individuals, supports the hypothesis on the dysfunctional organelles which, together with toxic α-synuclein conformers, are accumulated in dopaminergic neurons, leading to their severe destruction. Here, SNCA is linked to Parkinson disease.