Gao et al. [182] analyzed the distribution of rs11136000, a single-nucleotide polymorphism in the CLU gene, among 791 PD patients (of which 19% had dementia) and 1580 matched controls, reporting that carriers of both T alleles (TT as compared to CT and CC) had a lower PD risk with odds ratio (OR) = 0.71 (95% CI: 0.55–0.92). Here, CLU is linked to Parkinson disease.