Disturbances in HDL lipid/protein profiles have been implicated in multiple NDDs [42] and were recently reviewed by Marsillach et al. [43] and Cervellati et al. [40], who focused on the implication of apolipoproteins A-I, E, and J (clusterin) [43], as well as PON1 [40,43], in Alzheimer’s disease (AD). This evidence concerns the gene CLU and Alzheimer disease.