TNF and pemphigus foliaceus: This favors the inflammatory mediators’ expression such as nuclear factor-activated nuclear cell enhancer (NF-κB), tumor necrosis factor (TNF), interleukin (IL)1, 6, 18, 22, 17a, inducible nitrogen oxide synthase (iNOS) [6,7], which completely destroy the lung architecture and induce fibrosis (PF).