COX10 and Menkes disease: In fact, longer exercise interventions have been shown to attenuate proteome deregulation in the skeletal muscle and CNS of the Mutator mouse model of MD [72] or mitigate myopathy and increase the lifespan of the cytochrome C oxidase assembly factor heme A: farnesyltransferase (COX10) knockout (Cox 10−/−) mouse model [73].