NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Moreover, polymorphisms found in Nrf2-related genes including SOD1 (rs2234694), SOD3 (rs2536512), GSTM1 (rs1056806), SOD2 (rs4880), and GPx1 (rs1800668) were prevalent in obese patients, and the last four were associated with increased risk of obesity [81].