In the last decade, it has become evident the relationship between reduced Nrf2 activity and the development of cardiovascular disorders in patients with obesity, diabetes mellitus, and atherosclerosis [100,101], confirming a plethora of studies using pathological models in isolated cells as well as in animals, where the low activity of the Nrf2-Keap1-ARE axis correlates with augmented oxidative stress and detrimental cellular effects. Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.