LDLR and atherosclerosis: Recently, using two different murine models of atherosclerosis, LDL receptor-deficient mice (LDLR−/−) and LDLR−/− mice expressing only apoB-100 (LDLR−/−ApoB100/100), demonstrated that Nrf2 deficiency delays early atherogenesis but, in later stages of the disease, promotes plaque instability [107].