Likewise, when reviewing the insulin data, HFD + Supplemented had the lowest levels of bloodstream insulin, even under HFD exposure (p < 0.0001 compared to all other experimental groups), as shown in Figure 4B. In the same way, the HOMA-IR (homeostatic model assessment of insulin resistance) was significantly decreased by the new nutraceutical (HFD + Supplemented) compared to the other experimental groups (p < 0.0001 compared to all other experimental groups), demonstrating an effect of the insulin sensitizer. Here, INS is linked to Insulin resistance.