SGK1 and hypertensive disorder: For example, high-fructose intake differentially affects SS and SR rats in such a way that, in SS rats, it induces hypertension by increasing Th17 cells, which secrete pro-inflammatory cytokine CD-17A and involves IL-23R-SGK1 axis, but SR rats seems to be protected by producing a large amount of anti-inflammatory cytokine IL-10, secreted by Treg cells [44].