MAP2K3 and HIV infectious disease: In the case of MAP2K3, a gene annotated in the modules HIV and immune signature, and hypermethylated in Late rebounders, its methylation levels are negatively correlated with viral load while a positive correlation is observed with the time from HIV infection to cART treatment initiation, the time with undetectable viremia in MAP and the time off cART (Figure S8d, h).