TLR4 and Sepsis: Sepsis is featured by the extremely high mortality which is regarded as a global health priority by the WHO, therefore, it is urgent to find the biomarker involving the development and progression of sepsis to stratify the patients and individualize their treatment, which might help to improve the prognosis of sepsis patients.1, 2, 3, 4, 5, 6 Previous studies have reported the regulation role of lnc‐GAS5 in sepsis.18, 24 For instance, one study shows lnc‐GAS5‐mediated miR‐23a‐3p promotes inflammation and cell apoptosis by targeting TLR4 in a cell model of sepsis.