Hence, lnc‐GAS5 is negatively related to SOFA‐Respiratory system score,30 (2) lnc‐GAS5 might inhibit the renal cell pyroptosis in sepsis‐induced renal injury though inhibiting miR‐579‐3p to activate SIRT1/PGC‐1 alpha/Nrf2 signaling pathway, therefore, lnc‐GAS5 negatively associated with SOFA‐Renal system score,17 (3) lnc‐GAS5 could inhibit the inflammatory process, which might regulate the coagulation process, therefore, the lnc‐GAS5 was related to the SOFA‐Coagulation score. This evidence concerns the gene SIRT1 and Sepsis.