In our study, we found that lnc‐GAS5 negatively correlated with Th17 cell and its secreted inflammatory cytokine (IL‐17A), also it negatively associated with CRP which might be explained that (1) lnc‐GAS5 inhibited the T cell differentiation into Th17 cells, therefore it negatively associated with Th17 cells and IL‐17A in sepsis, and (2) lnc‐GAS5 restrained the inflammatory response, hence, it negatively correlated with CRP level in sepsis patients. This evidence concerns the gene IL17A and Sepsis.