NPPB and AL amyloidosis: In a pivotal study on patients with AL amyloidosis [33], Palladini et al. demonstrated that NT-proBNP retained a good diagnostic accuracy for cardiac involvement even in case of reduced glomerular filtration rate (GFR), using a higher NT-proBNP cutoffs (332 pg/mL, 543 pg/mL and 2642 pg/mL for patients with GFR ≥ 60, 60–15 and < 15 mL/min/1.73 m2, respectively) [34].