To investigate whether these expression patterns translated to human islets, we investigated single-cell expression of UCN3 and CRHR2 as well as UCN1, UCN2 and GLP1R in human alpha cells, beta cells and delta cells from non-diabetic donors and donors with type 2 diabetes by re-analysing publicly available raw RNA sequencing data [11] (Fig. 6e). Here, UCN3 is linked to type 2 diabetes mellitus.