RB1 and retinoblastoma: The product of RB1 gene is a tumor suppressor and regulator of cell cycle progression, affected in many malignancies56 and classified as a causative factor in Rb.57 Present management protocols of Rb aim not only to protect the eye but also its visual function.58 Preserving eye-sight proves to be difficult in recurrent malignant growths, leading to extended retinal damage or even enucleation.47,59,60 Further progression in management protocols as well as design of new efficacious therapies require detailed understanding of Rb tumors at the molecular and cellular level.