RB1 and retina neoplasm: Genetic and phenotypic divergence between spontaneous human Rb and induced mouse retinal tumors can be bypassed by taking advantage of recent developments in somatic cell-induced reprogramming,24,25 CRISPR/Cas9 gene editing26-29 and 3D retinal organoid generation from pluripotent stem cells.30-37 Zeng et al38 and Vincent et al39 reported generation of Rb patient-specific induced pluripotent stem cell (iPSC) lines heterozygous for RB1 gene from skin fibroblasts and orbital adipose tissue, respectively.