Together these data indicate expression of other retinal cell type markers in the Rb proliferating cone clusters in both Rb tumors and pRB-depleted hESC organoids, a finding which is corroborated by a very recent publication showing expression of less differentiated cones together with neuronal/ganglion-cell markers in 102 Rb tumor samples.51 This evidence concerns the gene RB1 and retinoblastoma.