Indeed, NOX2 regulation may be AMPK-dependent as it was shown that increasing AMPK activity could reduce NOX2-dependent oxidative stress and myocardial injury.68 Recently hyperglycaemia-associated increases in cardiomyocyte ROS were shown to involve the activation of CaMKII by O-GlcNAcylation and a subsequent generation of ROS by NOX2.69 The gene discussed is CYBB; the disease is Hyperglycemia.