Here, we show that ADM did not affect the cell proliferation in medium with 5.6 mM glucose, but did inhibit cell proliferation in medium with 16.7mM glucose in a dose-dependent manner (Figs 4 and 5), and this inhibition was blocked by pretreatment of cells with ADM22-52, indicating that enhanced ADM inhibitory action in hyperglycemia may result from glucose-stimulated ADM receptor overexpression, and the ADM inhibitory effect are mediated through ADM receptors. This evidence concerns the gene ADM and Hyperglycemia.