Based on this analysis, we observed that JH-/- mice developed a similar SI enteropathy to that observed in CD19-/- mice (Fig 1A) characterized by significant increases in all four parameters of disease (two-way ANOVA, Fstat1,48 (main effect ’genotype’) = 118.3, p<0.0001) compared to WT animals (Fig 1B). Here, CD19 is linked to Abnormal intestine morphology.