PTEN and glioblastoma: Across all 55 glioblastoma samples, one hundred and sixty-six actionable mutations were detected in 36 genes (Fig 1A, S1 Fig and S5–S7 Tables) with TP53, CDKN2A, EGFR, PTEN, CDKN2B, NF1, CDK4, IDH1, PIK3R1 and RB1 being the ten most frequently mutated (Fig 1B).