Furthermore, significant associations were identified between tumour classification and overall UP III pattern, loss of UP III expression, overall CK 7 pattern and COX-2 pattern, as well as between depth of neoplastic cell infiltration into the urinary bladder wall and overall UP III pattern, loss of UP III, overall CK 7 pattern, loss of CK 7 expression and COX-2 pattern. The gene discussed is UPP1; the disease is neoplasm.