MTHFR and coronary artery disorder: Our results showed that mothers who carried the MTHFR 677CT or TT and MTRR 524CT or TT genotypes combination in the absence of folic acid supplementation during pregnancies had six-fold (OR = 6.909, p-value = 0.027; 95% CI—1.23 ± 38.51) and four-fold (OR = 4.75, p-value = 0.040; 95% CI—1.067 ± 21.44) increased odds of having a DS child with CHD, respectively, as compared to mothers who had taken the folic acid supplementation (Table 3).