Therefore, in the present study, we studied MTHFR (C677T and A1298C) and MTRR (C524T and A66G) gene polymorphisms in Group I (mothers of DS with CHD), II (mothers of DS without CHD), and III (healthy age-matched mothers who had delivered healthy offspring) along with above-mentioned maternal risk factors. This evidence concerns the gene MTHFR and coronary artery disorder.