TP53 and central nervous system cancer: Exposure of C6 glioma cells and p53 deleted mouse embryonic fibroblasts to FB1 significantly increased the content of MDA in C6 glioma cells, increased the apoptotic rate of C6 glioma cells, and increased the levels of 8-OH-dG and DNA fragments in C6 glioma cells in a dose-dependent manner [41].