APP and neurodegenerative disease: Recently, primary cultures of this brain area have been used to investigate aspects related to neurodegenerative diseases, such as the effect produced by toxic aggregates of alpha-synuclein [41], the antioxidant and neuroprotective effects of zolpidem [43], or the protective effects of cannabinoid receptor 2 agonist compounds against neuronal toxicity induced by the accumulation of beta-amyloid peptides [44].