RHOA and Hepatic fibrosis: In summary, the molecular mechanisms that regulate the polarization of macrophages toward M2 and the activation of the associated RhoA-MAPK signaling pathway during Echinococcus multilocularis infection the molecular mechanism of activation Echinococcus multilocularis infection, new intervention pathways and drug targets for regulating the polarization phenotype of macrophages and mitigating or inhibiting the development and treatment of liver fibrosis caused by Echinococcus multilocularis infection.