POMC and diabetes mellitus: Investigations into secondary causes of diabetes were performed and identified ACTH-dependent hypercortisolism with an elevated 24-hour UFC (438nmol/24 hr, normal range < 150 nmol/24 hr), lack of cortisol suppression on a 1-mg overnight dexamethasone suppression test, and an elevated ACTH (21 pmol/L, reference range < 14pmol/L).